depot antiepileptic drug: Ethical implications

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Journal of Clinical Research and Bioethics  is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide.

Philosophy includes both analysis and synthesis. Analysis focuses on central concepts in a domain, for example, informed consent, death, medical futility, and health. It is argued that analysis should avoid oversimplification. The synthesis or synoptic dimension prompts people to explain how their views have logical assumptions and implications. In addition to the conceptual elements are the evaluative and empirical dimensions. Among its functions, philosophy can be a form of prophylaxis—helping people avoid some commonly accepted questionable theories. Generally, recent philosophy has steered away from algorithms and deductivist approaches to ethical justification. In bioethics, philosophy works in partnership with a range of other disciplines, including pediatrics and neurology.

Depot medications have been used for long-term treatment of many different medical conditions (schizophrenia, opioid addiction) and for prevention of pregnancy (birth control). In addition, proposals for depot medication for antidepressants have been made as a possible treatment for chronic depression. For the treatment of chronic epilepsy, there are currently no depot antiepileptic drugs (AEDs). However, there may be a role for them. Depot AEDs could improve medication adherence rates, thereby reducing the morbidity and mortality that are associated with ongoing seizures. This could help to reduce hospital costs for people with epilepsy. Potential patient populations that could benefit from a depot AED include patients with forgetfulness, socioeconomic barriers to access of daily oral medications, impaired gastric absorption or dysphagia, comorbid epilepsy and psychiatric disease, and personal preference to avoid the inconvenience of taking a medication daily or even multiple times per day. In this article, we review reasons to create a depot AED and the outcomes of doing so in the context of the pillars of bioethics: beneficence (to act in a patient's best interest), autonomy (to respect a patient as an individual and honor their preferences), nonmaleficence (to do no harm), and justice (to treat all persons fairly and equally).

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Eliza Grace
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Journal of Clinical Research and Bioethics
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